Suicidal Behavior Is Associated with Reduced Corpus Callosum Area
Identifieur interne : 006692 ( Main/Exploration ); précédent : 006691; suivant : 006693Suicidal Behavior Is Associated with Reduced Corpus Callosum Area
Auteurs : Fabienne Cyprien [France] ; Philippe Courtet [France] ; Alain Malafosse [France, Suisse] ; Jerome Maller [Australie] ; Chantal Meslin [Australie] ; Alain Bonafe [France] ; Emmanuelle Le Bars [France] ; Nicolas Menjot De Champfleur [France] ; Karen Ritchie [France, Royaume-Uni] ; Sylvaine Artero [France]Source :
- Biological psychiatry : (1969) [ 0006-3223 ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Suicide.
English descriptors
Abstract
Background: Corpus callosum (CC) size has been associated with cognitive and emotional deficits in a range of neuropsychiatric and mood disorders. As such deficits are also found in suicidal behavior, we investigated specifically the association between CC atrophy and suicidal behavior. Methods: We studied 435 right-handed individuals without dementia from a cohort of community-dwelling persons aged 65 years and over (the ESPRIT study). They were divided in three groups: suicide attempters (n = 21), affective control subjects (AC) (n = 180) without history of suicide attempt but with a history of depression, and healthy control subjects (HC) (n = 234). T1-weighted magnetic resonance images were traced to measure the midsagittal areas of the anterior, mid, and posterior CC. Multivariate analysis of covariance was used to compare CC areas in the three groups. Results: Multivariate analyses adjusted for age, gender, childhood trauma, head trauma, and total brain volume showed that the area of the posterior third of CC was significantly smaller in suicide attempters than in AC (p = .020) and HC (p = .010) individuals. No significant differences were found between AC and HC. No differences were found for the anterior and mid thirds of the CC. Conclusions: Our findings emphasize a reduced size of the posterior third of the CC in subjects with a history of suicide, suggesting a diminished interhemispheric connectivity and a possible role of CC in the pathophysiology of suicidal behavior. Further studies are needed to strengthen these results and clarify the underlying cellular changes leading to these morphometric differences.
Affiliations:
- Australie, France, Royaume-Uni, Suisse
- Angleterre, Canton de Genève, Grand Londres, Languedoc-Roussillon, Occitanie (région administrative), Victoria (État)
- Genève, Londres, Melbourne, Montpellier
- Université de Genève
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 001980
- to stream PascalFrancis, to step Corpus: 002203
- to stream PascalFrancis, to step Curation: 004564
- to stream PascalFrancis, to step Checkpoint: 001643
- to stream Main, to step Merge: 006A94
- to stream Main, to step Curation: 006692
Le document en format XML
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University of Montpellier I</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Centre Hospitalier Regional Universitaire de Montpellier</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Courtet, Philippe" sort="Courtet, Philippe" uniqKey="Courtet P" first="Philippe" last="Courtet">Philippe Courtet</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut National de la Sante et de la Recherche Medicale (INSERM), Unit 1061, Neuropsychiatry, Epidemiological and Clinical Research</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>La Colombière Hospital; University of Montpellier I</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Centre Hospitalier Regional Universitaire de Montpellier</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Malafosse, Alain" sort="Malafosse, Alain" uniqKey="Malafosse A" first="Alain" last="Malafosse">Alain Malafosse</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut National de la Sante et de la Recherche Medicale (INSERM), Unit 1061, Neuropsychiatry, Epidemiological and Clinical Research</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>La Colombière Hospital; University of Montpellier I</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Department of Psychiatry, University of Geneva</s1><s2>Geneva</s2><s3>CHE</s3><sZ>3 aut.</sZ></inist:fA14><country>Suisse</country><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName><orgName type="university">Université de Genève</orgName></affiliation></author><author><name sortKey="Maller, Jerome" sort="Maller, Jerome" uniqKey="Maller J" first="Jerome" last="Maller">Jerome Maller</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Monash Alfred Psychiatry Research Centre, The Alfred and Monash University School of Psychology and Psychiatry</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>4 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Meslin, Chantal" sort="Meslin, Chantal" uniqKey="Meslin C" first="Chantal" last="Meslin">Chantal Meslin</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Centre for Mental Health Research, Australian National University</s1><s2>Canberra</s2><s3>AUS</s3><sZ>5 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Canberra</wicri:noRegion></affiliation></author><author><name sortKey="Bonafe, Alain" sort="Bonafe, Alain" uniqKey="Bonafe A" first="Alain" last="Bonafe">Alain Bonafe</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Centre Hospitalier Regional Universitaire de Montpellier</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Le Bars, Emmanuelle" sort="Le Bars, Emmanuelle" uniqKey="Le Bars E" first="Emmanuelle" last="Le Bars">Emmanuelle Le Bars</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>La Colombière Hospital; University of Montpellier I</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Centre Hospitalier Regional Universitaire de Montpellier</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Menjot De Champfleur, Nicolas" sort="Menjot De Champfleur, Nicolas" uniqKey="Menjot De Champfleur N" first="Nicolas" last="Menjot De Champfleur">Nicolas Menjot De Champfleur</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>La Colombière Hospital; University of Montpellier I</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Centre Hospitalier Regional Universitaire de Montpellier</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author><author><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut National de la Sante et de la Recherche Medicale (INSERM), Unit 1061, Neuropsychiatry, Epidemiological and Clinical Research</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>La Colombière Hospital; University of Montpellier I</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="07"><s1>Faculty of Medicine (KR), Imperial College, St. Mary's Hospital</s1><s2>London</s2><s3>GBR</s3><sZ>9 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Artero, Sylvaine" sort="Artero, Sylvaine" uniqKey="Artero S" first="Sylvaine" last="Artero">Sylvaine Artero</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Institut National de la Sante et de la Recherche Medicale (INSERM), Unit 1061, Neuropsychiatry, Epidemiological and Clinical Research</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>La Colombière Hospital; University of Montpellier I</s1><s2>Montpellier</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Occitanie (région administrative)</region><region type="old region">Languedoc-Roussillon</region><settlement type="city">Montpellier</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Biological psychiatry : (1969)</title><title level="j" type="abbreviated">Biol. psychiatry : (1969)</title><idno type="ISSN">0006-3223</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Biological psychiatry : (1969)</title><title level="j" type="abbreviated">Biol. psychiatry : (1969)</title><idno type="ISSN">0006-3223</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Corpus callosum</term><term>Nuclear magnetic resonance imaging</term><term>Suicide</term><term>Suicide attempt</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Suicide</term><term>Tentative suicide</term><term>Corps calleux</term><term>Imagerie RMN</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Suicide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Corpus callosum (CC) size has been associated with cognitive and emotional deficits in a range of neuropsychiatric and mood disorders. As such deficits are also found in suicidal behavior, we investigated specifically the association between CC atrophy and suicidal behavior. Methods: We studied 435 right-handed individuals without dementia from a cohort of community-dwelling persons aged 65 years and over (the ESPRIT study). They were divided in three groups: suicide attempters (n = 21), affective control subjects (AC) (n = 180) without history of suicide attempt but with a history of depression, and healthy control subjects (HC) (n = 234). T1-weighted magnetic resonance images were traced to measure the midsagittal areas of the anterior, mid, and posterior CC. Multivariate analysis of covariance was used to compare CC areas in the three groups. Results: Multivariate analyses adjusted for age, gender, childhood trauma, head trauma, and total brain volume showed that the area of the posterior third of CC was significantly smaller in suicide attempters than in AC (p = .020) and HC (p = .010) individuals. No significant differences were found between AC and HC. No differences were found for the anterior and mid thirds of the CC. Conclusions: Our findings emphasize a reduced size of the posterior third of the CC in subjects with a history of suicide, suggesting a diminished interhemispheric connectivity and a possible role of CC in the pathophysiology of suicidal behavior. Further studies are needed to strengthen these results and clarify the underlying cellular changes leading to these morphometric differences.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>Royaume-Uni</li><li>Suisse</li></country><region><li>Angleterre</li><li>Canton de Genève</li><li>Grand Londres</li><li>Languedoc-Roussillon</li><li>Occitanie (région administrative)</li><li>Victoria (État)</li></region><settlement><li>Genève</li><li>Londres</li><li>Melbourne</li><li>Montpellier</li></settlement><orgName><li>Université de Genève</li></orgName></list><tree><country name="France"><region name="Occitanie (région administrative)"><name sortKey="Cyprien, Fabienne" sort="Cyprien, Fabienne" uniqKey="Cyprien F" first="Fabienne" last="Cyprien">Fabienne Cyprien</name></region><name sortKey="Artero, Sylvaine" sort="Artero, Sylvaine" uniqKey="Artero S" first="Sylvaine" last="Artero">Sylvaine Artero</name><name sortKey="Artero, Sylvaine" sort="Artero, Sylvaine" uniqKey="Artero S" first="Sylvaine" last="Artero">Sylvaine Artero</name><name sortKey="Bonafe, Alain" sort="Bonafe, Alain" uniqKey="Bonafe A" first="Alain" last="Bonafe">Alain Bonafe</name><name sortKey="Courtet, Philippe" sort="Courtet, Philippe" uniqKey="Courtet P" first="Philippe" last="Courtet">Philippe Courtet</name><name sortKey="Courtet, Philippe" sort="Courtet, Philippe" uniqKey="Courtet P" first="Philippe" last="Courtet">Philippe Courtet</name><name sortKey="Courtet, Philippe" sort="Courtet, Philippe" uniqKey="Courtet P" first="Philippe" last="Courtet">Philippe Courtet</name><name sortKey="Cyprien, Fabienne" sort="Cyprien, Fabienne" uniqKey="Cyprien F" first="Fabienne" last="Cyprien">Fabienne Cyprien</name><name sortKey="Cyprien, Fabienne" sort="Cyprien, Fabienne" uniqKey="Cyprien F" first="Fabienne" last="Cyprien">Fabienne Cyprien</name><name sortKey="Le Bars, Emmanuelle" sort="Le Bars, Emmanuelle" uniqKey="Le Bars E" first="Emmanuelle" last="Le Bars">Emmanuelle Le Bars</name><name sortKey="Le Bars, Emmanuelle" sort="Le Bars, Emmanuelle" uniqKey="Le Bars E" first="Emmanuelle" last="Le Bars">Emmanuelle Le Bars</name><name sortKey="Malafosse, Alain" sort="Malafosse, Alain" uniqKey="Malafosse A" first="Alain" last="Malafosse">Alain Malafosse</name><name sortKey="Malafosse, Alain" sort="Malafosse, Alain" uniqKey="Malafosse A" first="Alain" last="Malafosse">Alain Malafosse</name><name sortKey="Menjot De Champfleur, Nicolas" sort="Menjot De Champfleur, Nicolas" uniqKey="Menjot De Champfleur N" first="Nicolas" last="Menjot De Champfleur">Nicolas Menjot De Champfleur</name><name sortKey="Menjot De Champfleur, Nicolas" sort="Menjot De Champfleur, Nicolas" uniqKey="Menjot De Champfleur N" first="Nicolas" last="Menjot De Champfleur">Nicolas Menjot De Champfleur</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name></country><country name="Suisse"><region name="Canton de Genève"><name sortKey="Malafosse, Alain" sort="Malafosse, Alain" uniqKey="Malafosse A" first="Alain" last="Malafosse">Alain Malafosse</name></region></country><country name="Australie"><region name="Victoria (État)"><name sortKey="Maller, Jerome" sort="Maller, Jerome" uniqKey="Maller J" first="Jerome" last="Maller">Jerome Maller</name></region><name sortKey="Meslin, Chantal" sort="Meslin, Chantal" uniqKey="Meslin C" first="Chantal" last="Meslin">Chantal Meslin</name></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Ritchie, Karen" sort="Ritchie, Karen" uniqKey="Ritchie K" first="Karen" last="Ritchie">Karen Ritchie</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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